慢性阻塞性肺疾病患者促血管生成素-2水平与脂代谢关系分析

摘要

目的：探讨慢性阻塞性肺疾病（COPD）患者脂代谢和血清促血管生成素-2（ANG-2）水平与病情严重程度的关系。方法选取慢性阻塞性肺疾病患者83例，同时选取体检的健康志愿者40例作为对照，比较不同缺氧程度、不同肺功能损害程度以及 COPD 合并肺心病患者的脂代谢指标和 ANG-2水平与健康对照间的差异；分析 COPD 患者中脂代谢指标和 ANG-2水平的相关关系。结果COPD 患者的总胆固醇（TC）和三酰甘油（TG）均低于健康对照组，COPD 患者的内脂素和 ANG-2均高于健康对照组，且差异有统计学差异（P ＜0．05）；COPD 患者的 TC 和 TG 水平随着缺氧程度和肺功能损害程度的增加而降低，内脂素和 ANG-2水平随着缺氧程度和肺功能损害程度的增加而升高，且差异有统计学意义（P ＜0．05）。单纯 COPD 患者的 TC 和TG 水平显著高于 COPD 合并肺心病的患者，单纯 COPD 患者的内脂素和 ANG-2水平显著低于 COPD 合并肺心病的患者，且差异有统计学意义（P ＜0．05）。COPD 患者的 TC（r ＝－0．258，P ＝0．004）和 TG（r ＝－0．240，P ＝0．007）水平与 ANG-2水平呈负相关；COPD 患者的内脂素水平与 ANG-2水平呈正相关（r ＝0．476，P ＜0．001）。结论脂代谢水平和 ANG-2水平随着 COPD患者的缺氧程度和肺功能损害程度而变化，且脂代谢水平和 ANG-2水平密切相关。%Objective To investigate the relationship between serum ANG-2 levels and lipid metabolism in patients with COPD.Meth-ods We selected 83 patients with chronic obstructive pulmonary disease and 40 cases of healthy volunteers having physical examina-tions as a control to compare hypoxia,impairment of lung function,lipid metabolism as well as ANG-2 levels between patients of COPD with pulmonary heart disease and healthy controls.The correlation between lipid metabolism and ANG-2 levels in patients with COPD was also analyzed.Results Total cholesterol (TC)and triglyceride (TG)were significantly lower in patients with COPD than the healthy controls,while visfatin and ANG-2 levels were significantly higher in patients with COPD than the healthy controls(P <0.05). TC and TG levels in COPD patients decreased with the worsening of hypoxia and impairment of lung function,while visfatin and ANG-2 levels increased with the worsening of hypoxia and impairment of lung function,and the difference was statistically significant (P <0.05).TC and TG levels were significantly higher in COPD patients than in COPD patients with pulmonary heart disease,and visfatin and ANG-2 levels were significantly lower COPD patients than in COPD patients with pulmonary heart disease (P <0.05).TC (r =-0.258,P =0.004)and TG (r =-0.240,P =0.007)of COPD patients were negatively correlated with ANG-2 levels,while visfatin levels of COPD patients were positively correlated with ANG-2 levels(r =0.476,P <0.001 ).Conclusions Lipid metabolism and ANG-2 levels change with the degree of hypoxia and impairment of lung function in patients with COPD,and lipid metabolism is closely related with ANG-2 levels.