黄芪、大黄的抗肾纤维化作用研究进展

摘要

事实上,肾纤维化是肾衰的必经途径.目前尚无良策治愈肾衰,但是肾纤维化却可以被阻止.肾纤维化包括肾小球硬化和肾间质纤维化,严重威胁人类健康,肾间质纤维化与肾衰关系更密切.肾纤维化是由多种病理机制造成.黄芪和大黄可通过干预其中一种或多种途径发挥抗肾纤维化的作用.黄芪、大黄是临床用于肾纤维化治疗中的重要药物.对黄芪、大黄中这两种中药做一综述是很有必要的.%In fact, renal fibrosis is the necessary way which leads to renal failure. There is no good way to cure renal failure. However,renal fibrosis can be prevented. Renal fibrosis includes glomerular sclerosis and renal interstitial fibrosis, and severe cases threaten the human health seriously. There is a more close relation betneen renal interstitial fibrosis and renal failure. Renal fibrosis involves several pathological mechanisms. Astragalus and rhubarb can resist or lighten renal fibrosis by intervening one way or more. Astragalus and rhubarb are important drugs for the treatment of renal fibrosis. A review is important to study these two Chinese herbal medicine.