北青龙衣抗肿瘤化学成分研究

摘要

Objective: To study the anti - tumor chemical constituents of Bei Qinglongyi (Pericarpium Juglandis). Methods: The chemical constituents of Bei Qinglongyi were extracted by using reflux extraction method with 95％ ethanol, isolated by macroporous adsorption resin, silica gel, and Sephadex LH - 20. The structures were elucidated on the basic of 1H - NMR, 13C - NMR and MS. Results: Seven compounds were isolated and identified as ursolic acid ethylice ster (1), 20 (R) - 24p - hydroxyl -20, 25 - epoxydammar - 3 - one(2), 1, 7- dihydroxy - 3, 6 - dimethoxy -anthraquino - ne(3), (E) - o - hydroxycinnamic acid(4), 4 - hydroxymethyl -2 - methoxyphenol(5), methyl gallate(6), and 5 - hydroxy -4 - methoxy - a - tetralone(7). Conclusion:Compounds 1 ～4 were isolated from this genus for the first time.%目的:研究北青龙衣抗肿瘤的化学成分.方法:使用95％乙醇回流提取,大孔吸附树脂、硅胶、 Sephadex LH-20等分离;1H-NMR,13C - NMR,MS鉴定结构.结果:分离得到7个化合物,分别鉴定为熊果酸乙酯(1),20(R) -24β-羟基-20,25 -环氧-达玛烷-3-酮(2),1,7-二羟基-3,6-二甲氧基蒽醌(3),反式邻羟基肉桂酸(4),4-羟甲基-2 -甲氧基苯酚(5),没食子酸甲酯(6),4 -甲氧基-5 -羟基-1 -四氢萘酮(7).结论:化合物1 ～4为首次从该属中分离得到.