肺炎支原体肺炎患儿T淋巴细胞亚群变化的临床意义

摘要

Objective:To detect the changes of T lymphocyte subsets in children with mycoplasma pneumoniae pneumonia ( MPP) for basis with immuno-logical therapy for MPP.Methods:Sixty children diagnosed as MPP in our hospital between July 2013 and December 2013 were included,and another 60 healthy children undergoing the physical examination at the out-patient in the corresponding period were recruited as controls.The peripheral blood was ob-tained from the two groups and measured for the levels of T lymphocyte subsets.Results:The levels of CD3 +,CD4 +,CD8 +and CD4 +/CD8 +were 69.12 ±8.07,37.76 ±8.22,27.96 ±9.28 and 1.53 ±0.56,respectively,for the in MPP group,whose CD3 +,CD4 +and CD4 +/CD8 +levels were signifi-cantly decreased,yet CD8 +level was markedly elevated as compared with the controls(P<0.01).Conclusion:Imbalanced T lymphocyte subsets were found in children with MPP,which suggests that cellular immune dysfunction may play an important role in the pathogenesis of mycoplasma pneumoniae pneumonia.%目的：检测肺炎支原体肺炎（ MPP）患儿机体细胞免疫功能的变化，为MPP免疫学治疗提供进一步依据。方法：选取2013年7～12月于本院确诊为MPP的患儿60例，对照组为同期门诊体检健康儿童60例，分别检测两组儿童外周静脉血中T淋巴细胞亚群的表达水平。结果：MPP组患儿的CD3+、CD4+、CD8+、CD4+／CD8+表达水平（ x¯±s，％）分别为69.12±8.07、37.76±8.22、27.96±9.28、1.53±0.56。与健康对照组儿童相比，MPP组患儿的CD3+、CD4+、CD4+／CD8+表达水平显著下降，而CD8+表达水平则显著升高（ P＜0.01）。结论：MPP患儿T淋巴细胞亚群表达失调，细胞免疫功能紊乱可能在MPP发病过程中起着重要作用。