术中自体血液回输对颅脑手术患者免疫功能的影响

摘要

Objective:To observe the effects of intraoperative autologous blood transfusion on immune function in patients undergoing craniocerebral opera-tion.Methods:110 patients undergoing craniocerebral surgery were randomLy divided into observational group(received autologous blood transfusion) and control group(received allogeneic blood transfusion)(n=55 for each).Results:①Patients in the two groups had no significant difference concerning the preoperative routine blood studies, coagulation indicator and immunologic function(P>0.05) ,yet patients in the observational group had significantly high-er red blood cell(RBC) , hemoglobin(Hb) ,IL-6 and IFN-γ levels than those in the control group at day 8 following operation(P<0.05); ②Patients in the observational group had lower infection rate than those in the control group (χ2=4.9495, P=0.0265).Conclusion:Intraoperative autologous blood transfusion can be effective for patients undergoing craniocerebral surgery, and have more advantages,including better maintenance of RBC and Hb as well as less effect on the immunity and lower postoperative infection.%目的:探讨术中自体血液回输对颅脑手术治疗患者免疫功能的影响.方法:将颅脑手术治疗且术中有输血的110例患者随机分为2组,每组55例,观察组术中采用自体血液回输治疗,而对照组术中采用异体输血治疗.结果:①手术前,两组患者血常规、凝血指标、免疫功能差异无统计学意义(P>0.05).术后第8天,观察组RBC、Hb、IL-6、IFN-γ高于对照组(P<0.05).②观察组术后感染率低于对照组,差异有统计学意义(χ2=4.9495,P=0.0265).结论:颅脑手术治疗患者术中采用自体血液回输的疗效良好,具有RBC及Hb维持效果好、免疫功能影响小、术后感染率低等优点.