Impact of anthocyanins and dietary carbohydrates on intestinal tumorigenesis in Apc(Min/+) mice.

摘要

Consumption of anthocyanins reduces the development of intestinal tumors in ApcMin/+ mice, whereas diets rich in sucrose increase intestinal tumor development. The aim of this study was to determine the efficacy of anthocyanins to reduce intestinal tumorigenesis in ApcMin/+ mice consuming diets rich in sucrose and other dietary carbohydrates. Mice were assigned to six different modified AIN-93G diets, which contained different carbohydrate sources (starch, sucrose, or glucose) and different doses of anthocyanins (0 or 1500 mg/kg) in a factorial design. To enhance tumor development, mice were injected for three consecutive weeks with azoxymethane (8 mg/kg) prior to dietary intervention. Mice consuming sucrose showed the largest colonic adenomas compared to mice consuming anthocyanin-sucrose, anthocyanin-glucose, glucose, and starch (P<0.05). These results demonstrate that anthocyanins and different carbohydrates influence intestinal adenoma development in ApcMin/+ mice; however, additional research is required to determine the mechanisms for the observed effects.