A Novel Cataplasma Matrix of Traditional Chinese Medicine

摘要

The present cataplasma matrices are most suitable for water-soluble drugs, and incompatible with the liposoluble active ingredient. The aim of this paper was to develop a cataplasma matrix that can be applicable to different drugs. The gellan gum and the konjaku were employed as the scaffold materials of the matrix. Mechanical properties of cataplasma matrices were affected primarily by the amounts of gellan gum, xanthan gum, konjaku and glycerin. The amounts of polyacrylic acid sodium and oligosaccharides influenced both the adhesive property and elongation of the matrix. The increase of the amount of the Xanthan gum caused a decrease of the elongation and the tensile strength of the matrix. Further, the elongation increased while the tensile strength decreased when the amount of glycerin rose. The formula of cataplasma matrix was optimized by the orthogonal method. A formulation was suggested with gellan gum 0.4 g, xanthan gum 0.03 g, konjac glue 0.1 g, glycerin 4 g, GAT 6 g, GAE 6 g, polyacrylic acid sodium 0.22 g, and sorbitol 3 g. The 180° peel strength, the tensile strength and the elongation at break were 3.043 N, 0.275 MPa and 91.05%, respectively. Furthermore, the drug-compatibilities of the matrix were investigated with baicalin, berberine and curcumin, which were used as the models of hydrophilic, poor-water-soluble and hydrophobic ingredients. The drug contents could reach 4.12%, 2.42% and 3.75% while the in vitro release rate were measured as, 361.79, 55.85 and 104.41 μg·cm-2·h-1 for baicalin, berberine and curcumin respectively. These results indicated that the obtained matrix had good drug-compatibility and drug-release properties for different ingredients.