STUDY ON ANTIHYPERTENSIVE PEPTIDE DERIVED FROM CHICKEN LEG BONE PROTEIN

摘要

IntroductionHypertension is a worldwide trend and is one of the major factors indicated for stroke, arteriosclerosis and heart failure (Brian and Rosario, 2005). Angiotension I converting enzyme, ACE (dipeptidyl carboxypeptidase, EC 3.4.15.1) is a zinc metal peptidase associated with rennin-angiotensin system, a main mechanism of blood pressure regulation. Therefore, ACE inhibition is an important target to develop medicines for pharmacologic treatment of hypertension (Li et al, 2004). Peptides from enzymatic hydrolysates, including ACE inhibitory, have been investigated for many years and have shown their biological activities. ACE inhibitory peptides derived from various sources of food proteins, released after hydrolysis or fermentation processing have been studied. In Taiwan, people prefer to consume deboned chicken meat products, especially parts of the chicken legs. As a result, more and more chicken leg bones are produced during processing. The purposes of this study are to develop ACE inhibitor derived from a hydrolysate of chicken leg bone protein and to orally administrate it in spontaneously hypertensive rats (SHR) to investigate its antihypertensive effects.