Molecular dynamics study of the conformational behavior of branched glycopeptides during the solid-phase synthesis.The effect of insert and terminal groups

摘要

In our previous study we used molecular dynamics to evaluate the effect of the gamma-Abu insert on the conformational behavior of glycodendrimers during their synthesis on a solid phase.In agreement with experiment,we found that the insert has detrimental effect on their synthetic feasibility due to increased incidence of back-folding.