Correlation Between Timing of Hepatitis B Immunoglobulin to The Effectiveness of Mother to Child Transmission Prevention Program

摘要

The Prevention Program for Hepatitis B from Mother to Child Transmission (PMTCT) was carried out in Pangkalpinang City, Bangka Belitung Province since 2016. Pregnant women detected HBsAg positive were recorded so their newborn could get Hepatitis B Immunoglobulin (HBIg). The aim of study to analyze the correlation between the timing of Hepatitis B Immunoglobulin (HBIg) to the effectiveness of Hepatitis B PMTCT program in Pangkalpinang City. This study using cross sectional approach. Number of research samples was 59 children born to HBsAg positive mothers, who were taken using consecutively sampling from HBIg recipient data of Pangkalpinang Health Office. Independent variables are the timing of HBIg, and completeness of the Hepatitis B immunization, that were known from the MCH books and interviews with mothers using questionnaires. Dependent variable is effectiveness of the Hepatitis B PMTCT program, that measured from HBsAg and AntiHBs testing of children using the Rapid Diagnostic Test (RDT). Data analysis using chi-square test. The results showed that 1 (1.7%) children with HBsAg were positive, and 29 (49.2%) children with Anti-HBs were positive. Based on the results of the chi-square test there is a significant correlation between the timing of HBIg administration (p-value = 0.007) and the completeness status of Hepatitis B immunization (p-value = 0.026) on the success of the Hepatitis B PMTCT program in Pangkalpinang City. The timing of HBIg is effective in preventing transmission of Hepatitis B from HBsAg positive mothers to their newborn. Recommendation for health workers to cause immunity or antibodies on child, the HBIg is given immediately or less than 12 hours after birth, and is supplemented with a completeness of Hepatitis B vaccine.