Role of the Cortisol Hormone, Interleukin-5 Level, and Asthma Control Ability in Atopy Persistent Asthma

摘要

Introduction: Asthma is a chronic inflammatory disorder of the respiratory tract. The interaction among several hormones and mediators causes asthma symptoms. This study aimed to identify a correlation between the cortisol hormone, interleukin-5 level, and asthma control in asthma atopy persistent. Materials and Methods: 39 atopic participants of asthma group and 26 participants of non-asthma group were taken from the medical record in Prof. Dr. Margono Soekarjo Purwokerto hospital Central Java Indonesia. Peripheral blood mononuclear cells were isolated 72 hours with house dust mite allergens stimulation. Plasma levels of cortisol hormone and interleukin-5 were measured using an enzyme-linked immunosorbent assay kit. The ability to control symptoms was assessed using the Asthma Control Questionnaire. Results and Conclusions: Based on statistical analysis the results showed that there were differences between cortisol levels of asthma and non-asthmatic groups (p=0.001), there was correlation cortisol hormone with interleukin-5 stimulation of house dust mites allergens (p=0.04), there was no correlation interleukin-5 stimulation of house dust mite with asthma control ability (p=0.42), and there was no correlation between the hormone cortisol and asthma control ability (p=0.38). Therefore, cortisol hormone healthy subject was higher than asthma subject and thus there was correlation of cortisol hormone and interleukin-5 house dust mite allergens, and there were no correlation interleukin-5 house dust mite allergens and cortisol hormone with asthma control ability.