The effect of asthma exercise on cortisol hormone and interleukin-5 in the Indonesian patients with persistent asthma

摘要

Background: Inflammatory respiratory tract involves the interaction of several mediators that will cause asthma symptoms. This study aimed to reveal the effect of asthma exercise on cortisol hormone and interleukin-5 (IL-5) in the Indonesian patients with persistent asthma. Methods: This is a pre and posttest-designed experimental study in the Prof. Dr. Margono Soekarjo Hospital at Purwokerto, Indonesia. The diagnosis of asthma was established according to the Global Initiative For Asthma 2017. IL-5 levels were determined from peripheral blood mononuclear cells, and cortisol hormone analysis was performed by enzyme-linked immunosorbent assay technique. All parameters were tested before and after performing asthma exercise 4 times/week in 8 weeks with a duration of 60 min. The Wilcoxon and Pearson tests were performed for the statistical analysis. Results: Asthma exercise significantly increased the cortisol hormone levels (P 0.0001) and significantly reduced the IL-5 levels (P = 0.005). However, there was no significant correlation between cortisol hormone and IL-5 (r = ?0.002, P = 0.989). Conclusions: Asthma exercise can increase the cortisol hormone levels and reduce pro-inflammatory IL-5. Asthma exercise should be provided as a nonpharmacologic treatment in patients with persistent asthma.