NEUROMAN: Reference computational human anatomical models for therapeutic peripheral nerve stimulation and safety investigations

摘要

Therapeutic electrical stimulation of peripheral nerves is a promising technique with a wide range of treatment applications. At the same time, the trend towards stronger magnetic fields and/or faster gradient switching in magnetic resonance imaging poses safety risks for patients, e.g., due to tissue heating and unwanted neurostimulation. To this end, we are developing reference human anatomical models with unprecedented details in the peripheral nervous system, connectivity to organs and muscles, and functionalized with compartmental nerve models to investigate interactions with neuronal electrophysiology. We employ these phantoms to investigate current safety guidelines.