CODON-OPTIMIZED RECOMBINANT PLASMID ENCODING VEGF AND FGF-2 AND METHODS TO STIMULATE PERIPHERAL NERVE REGENERATION AND TREAT NERVE DAMAGE IN HUMANS

摘要

The invention relates to medicine, and more particularly to neurosurgery andtrauma surgery, andcan be used for stimulating nerve regeneration through the use of a genetherapeutic constructwhich codes for vascular endothelial growth factor (VEGF) and fibroblastgrowth factor (FGF-2).The gene therapeutic construct that codes for the two factors is based on acodon-optimizedrecombinant plasmid. The gene therapeutic construct can be introduced eitherdirectly into adamaged nerve or into the perineural tissues either during surgery or in thepost-operative period.The invention significantly improves the outcomes of the reconstructivetreatment of damagedperipheral nerves.