Self-assembled peptide targets integrin mediated cancer cell migration

摘要

Integrins are a large family of transmembrane receptors implicate in cancer cell invasion and migration through interaction between proteins of intracellular signaling pathways and extracellular matrix proteins.1,2 Laminin-111, an extracellular matrix protein, contains many bioactive peptide sequences that interact with integrins and cell surface heparan sulfate proteoglycan.3