Development of Nickel-Catalyzed Cycloaddition of Benzothiophenes and Alkynes; DFT Calculation, Spectroscopy and Synthetic Experiment

摘要

The cleavage of C–S bonds in sulfur-containing aromatic compounds by transition-metal complexes has been widely studied in order to obtain mechanistic insight into hydrodesulfurization process, and various kinds of transition-metal-complexes can be applied to the reaction. Especially, C–S bond scissions of benzothiophenes require dearomatization of 10π-electron system, and can be accomplished by using both transition-metal catalysts and organometallic reagents such as Grignard reagents to obtain cross-coupling products.