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Protein Adsorption and Adhesion of Blood Platelets on Silicone Rubber under Static and Dynamic Flow Conditions

机译:静态和动态流动条件下硅橡胶上血小板的蛋白质吸附和粘附

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Understanding the spontaneous protein adsorption on biomaterial surfaces is a key element to evaluate their thrombogenicity and especially their propensity to trigger the adhesion of blood platelets (thrombocytes). In this work, the adhesion of two proteins (bovine fibrinogen and bovine serum albumin) on silicone rubber and the thrombocyte adhesion on different preadsorbed protein layers has been investigated under static and dynamic flow conditions. It has been shown that proteins do not adhere equally to silicone rubber and that both the composition of protein layer and the flow conditions influence the thrombocyte adhesion.
机译:了解生物材料表面上的自发蛋白质吸附是评估它们的血栓形成度的关键因素,特别是它们触发血小板(血小板)的粘附性的倾向。在这项工作中,在静态和动态流动条件下,研究了两种蛋白质(牛纤维蛋白原和牛血清白蛋白)对硅橡胶的粘附和不同预色蛋白质层上的血小板粘附。已经表明,蛋白质不能同样地粘附到硅橡胶,并且蛋白质层的组成和流动条件都影响血小板粘附。

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