W-benzyl chitosan in situ forming antimicrobial gel for periodontitis treatment

摘要

The objectives of research were to synthesize N-benzyl chitosan and to investigate A'-benzyl chitosan on the properties of in situ forming gel such as viscosity, syringeability, drug release and antimicrobial activity against Porphyromonas gingivalis. A'-benzyl chitosan was synthesized and determined by FTIR. The increased amount of A'-benzyl chitosan apparently increased the viscosity and syringeability of this system. A'-benzyl chitosan gel could prolong the release of doxycycline hyclate and showed the antimicrobial activity against Porphyromonas gingivalis. N-benzyl chitosan systems could be delivered from syringe through needle for periodontitis treatment.