The Research Progress of Transforming Growth Factor (TGF - Beta) Gene Regulation and Invasion and Metastasis of Pancreatic Cancer

摘要

Transforming growth factors TGF is a kind of a superfamily of peptides, which have strong sensitivity to cell proliferation、differention and transfer, its function and its structure are very complicated, and it is a cell factor which widely exist in multiple cells. There are more and more attention on it in the recent years, especially the relation with the tumor is become a key point. TGF-βcan inhibit related proteins and gene regulation at the early stages of the tumor so can effect the cell proliferation, but at the late stages the tumor, TGF-β can also promote the invasion and matastasis of tumor cells. The important feature of pancreatic cancer is a highly mortality rate. But TGF-β have two-direction adjust effect to tumor. This article is mainly to the TGF - beta gene expression and the mechanisms and the invasion and metastasis of pancreatic cancer are reviewed in this paper.