Objective To explore the relationship between the expression of VEGF and TGF-β1 in naso-pharyngeal carcinoma and the clinical characteristics and prognosis of nasopharyngeal carcinoma patients. Meth-ods The expression of VEGF and TGF-β1 in the local middle-late nasopharyngeal carcinoma tissue of 96 patients was detected using immunohistochemistry.The correlation and the prognosis analysis were analyzed in combination with their clinical characteristics and prognosis. Results Expression rate of VEGF was 66.7% and that of TGF-β 1 53.1%.The expression of VEGF and TGF-β1 were positively correlated in the advanced nasopharyngeal carcino-ma.Both VEGF and TGF-β1 had significant correlation with lymphatic metastasis.The effects of VEGF and TGF-β1 on MFS were analyzed by Cox single factor and the results showed that VEGF positive was an adverse prognostic factor(P<0.05).The effects of age,sex,lymphatic metastasis,local invasion,VEGF and TGF-β1 on MFS were analyzed with Cox multifactor analysis and the results showed that VEGF positive was an adverse prognostic factor (P < 0.01). Conclusion The detection of VEGF and TGF-β1 protein in nasopharyngeal carcinoma may help to predict the metastasis of nasopharyngeal carcinoma.%目的 本研究探讨鼻咽癌组织中血管内皮生长因子(VEGF)、转化生长因子-β1(TGF-β1)的表达与鼻咽癌患者临床特点及预后的关系.方法 用免疫组化法检测96例局部中晚期鼻咽癌组织中VEGF、TGF-β1的表达情况,结合其临床特点及预后,分析其相关性并对其预后进行多因素综合分析.结果 VEGF阳性的表达率66.7%、TGF-β1阳性的表达率53.1%.VEGF和TGF-β1在中晚期鼻咽癌的表达成正相关.VEGF和TGF-β1均与淋巴转移有显著相关性.用Cox单因素相关分析VEGF、TGF-β1对MFS的影响.结果显示,VEGF阳性为不良预后因素(P<0.05).用Cox多因素相关分析年龄、性别、淋巴转移、局部侵犯、VEGF和TGF-β1对MFS的影响.结果显示:VEGF阳性为不良预后因素(P<0.01).结论 通过对鼻咽癌组织当中VEGF和TGF-β1蛋白的表达情况的检测,可能有助于对鼻咽癌转移的预测及预后评价.
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