Preparation and Anti-Tumor Activity of Polysaccharides From Phellinus Pini Mycelia

摘要

Polysaccharides PSⅠand PSⅡwere isolated from liquid-cultured mycelia of Phellinus pini. The average molecular weight: PSⅠ36 kDa, PSⅡ49 kDa; sulfate content: PSⅠ5.25%, PSⅡ0.65%; monosaccharide composition: PS Ⅰ glucose, galactose and mannitose; PS Ⅱ glucose, mannitose and xylose. Anti-tumor activities of PSⅠand PSⅡ(400 mg/kg·d, i.g.) were investigated in S180-bearing mice. Results indicated that PSⅠand PSⅡsignificantly inhibited the growth of S180-solid tumors. PSⅠand PSⅡeffectively protected immune organs (thymus and spleen) and increased activities of immune cells (NK cells, macrophages, T and B lymphocytes). Results suggest that polysaccharides PSⅠand PSⅡfrom Phellinus pini have potential anti-tumor activities, which might attributed partly to their immunomodulatory properties.