Synthesis and H~+/K~+-ATPase Inhibitory Activity of 2-phenyl-6,7-dihydrobenzofuran-4(5H)-one Oxime Ether Derivatives

摘要

Three pairs of 2-phenyl-6,7-dihydrobenzofuran-4(5H)-one oxime and corresponding oxime ether isomers were synthesized and separated as potential anti-ulcer agent. Their structures were characterized by NMR, IR, ESI-MS and elemental analysis. Preliminarily H~+/K~+-ATPase activity evaluation indicated that all the target compounds had a better inhibitory effect than the commercial omeprazole with the IC50 of 2.0-30.0 μM.