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OXIME ETHER DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY
OXIME ETHER DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY
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机译:具有脂氧合酶抑制活性的环氧醚衍生物
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摘要
The present invention provides certain substituted oxime ether compounds which inhibit lipoxygenase enzyme activity and are useful in the treatment of allergic and inflammatory disease states. The compounds of this invention have structure (I) where M is hydrogen, a pharmaceutically acceptable cation, or a pharmaceutically acceptable metabolically cleavable group; p and q are independently zero or one, with the proviso that (i) p and q may not both be the same; (ii) when p is one and q is zero, R is selected from the group consisting of hydrogen, straight or branched alkyl of from one to twelve carbon atoms, and cycloalkyl of from three to eight carbon atoms; and (iii) when p is zero and q is one, R is selected from the group consisting of hydrogen, alkyl of from one to twelve carbon atoms, cycloalkyl of from three to eight carbon atoms, and -NR1R2. L1 is a direct bond or is selected from the group consisting of alkyl of from one to six carbon atoms, alkylenyl, of from one to six carbon atoms, and alkynyl of from two to six carbon atoms; L2 is a direct bond or is alkyl of from one to six carbon atoms; Z is selected from the group consisting of hydrogen, alkyl of from one to six carbon atoms, and halosubstituted alkyl of from one to six carbon atoms; and A is optionally substituted carbocyclic or heterocyclic aryl, arylalkyl, or aryloxy.
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机译:本发明提供某些取代的肟醚化合物,它们抑制脂氧合酶的活性,可用于治疗过敏性和炎性疾病。本发明的化合物具有结构(Ⅰ),其中M是氢,可药用的阳离子,或可药用的代谢可裂解基团; p和q独立地为零或一,条件是(i)p和q可能不相同; (ii)当p为1且q为0时,R选自氢,具有1至12个碳原子的直链或支链烷基和具有3至8个碳原子的环烷基; (iii)当p为零且q为1时,R选自氢,碳数1至12的烷基,碳数3至8的环烷基和-NR 1 R 2。 L1是直接键或选自由1-6个碳原子的烷基,1-6个碳原子的亚烷基和2-6个碳原子的炔基组成的组; L 2为直接键或为具有1-6个碳原子的烷基; Z选自氢,1-6个碳原子的烷基和1-6个碳原子的卤代烷基。 A是任选取代的碳环或杂环芳基,芳基烷基或芳氧基。
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