Adaptive and Robust Linearizing Control Strategies for Fed-Batch Cultures of Microorganisms Exhibiting Overflow Metabolism

摘要

Linearizing control is a popular approach to control bioprocesses, which has received considerable attention is the past several years. This con-trol approach is however quite sensitive to modeling uncertainties, thus requiring some on-line parametric adaptation so as to ensure performance. In this study, this usual adaptive strategy is compared in terms of implementation and perfor-mance to a robust strategy, where the controller has a fixed parametrization which is determined using the LMI framework so as to ensure robust stability and per-formance. Fed-batch cultures of yeast and bacteria are considered as application examples.