Microwave Solid Phase Synthesis of Natriuretic Peptide Sequences Derived from the Venom of Native and Exotic Lizards

摘要

Prior to 2006 it was thought that advanced snakes and helodermatid lizards (Gila monster and Bearded lizard) were the only two reptile lineages that possessed venom delivery systems, and the lizard system was thought to have evolved independently from the snake venom system [1]. Recent phylogenic analysis of sequence data from cDNA libraries constructed from the mandibular and maxilliary glands of anguimorph and iguanian lizards (which includes the heladermatids) has shown that they are the closest relatives of snakes. Together they represent a well-resolved venomous clade possessing protein-secreting oral glands. Sequencing identified nine different toxin sequences present in each venomous lizard species.