Peptidomic identification of novel neuroendocrine regulatory peptide-1 and -2

摘要

Peptides play crucial roles in many physiological events as hormones, neurotransmitters and local mediators. Therefore, the database for endogenous peptides is recognized to be useful for discovery of bioactive peptides or biomarkers, if available. Recent advances in peptidomics that mainly depends on technological progress in mass spectrometry (MS) have enabled us to identify a great number of peptides in a target tissue or cells. However, most peptides in the tissue are assumed to be degradation products of proteins, since endogenous peptides are present in extremely low concentrations and proteins abundantly present in the tissue are metabolically converted into peptides by degradation proteases.