CRLX288, a Novel Polymeric Nanoparticle, Overcomes Many of the Delivery Hurdles Associated With the Parent Drug

摘要

Optimal drug therapy requires maximizing drug delivery to the intended target while minimizing drug dissemination to off-target tissues. Hurdles associated with optimizing drug delivery include: achieving a high drug concentration in target tissues, moving the drug across cel membranes, overcoming drug resistance mechanisms, and protecting the drug’s integrity until it reaches its intracellular target.