DNA-Sensors Using a Water-Soluble, Cationic Poly(thiophene) Derivative

摘要

We designed a novel cationic, water-soluble polythiophene derivative which can easily transduce oligonucleotide hybridization into optical or electrical signal. This polymeric sensor proved to be specific enough to distinguish between single nucleotide mismatches. This simple methodology has the potential to be integrated into various applications involving detection and identification of oligonucleotides.