C-H Bond Activation by Iridium and Rhodium Complexes: Catalytic Hydrogen-Deuterium Exchange and C-C Bond-Forming Reactions

摘要

The metal-mediated activation of carbon-hydrogen bonds has the potential of leading to important fundamental insights, as well as to advances in large-scale industrial and synthetic organic chemical processes. Our initial finding of C-H oxidative addition reactions in low-valent iridium (I) complexes was followed by a more recent discovery and exploration of C-H activation processes at Ir (III) centers. This paper reviews recent studies of the Ir (III) reaction that include work directed toward elucidation of its reaction mechanism and the development of catalytic hydrogen/deuterium exchange reactions. The article also discusses collaborative studies of rhodium (I)-catalyzed reactions that provide a method for adding complexity to a range of carbo- and heterocyclic arene compounds with structures analogous to those found in physiologically active organic compounds.