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Prediction of the solubility of active pharmaceutical ingredients under varying conditions of pH and temperature using the SAFT-y Mie equation of state(PPT)

机译：使用状态的Saft-Y Mie型（PPT）预测活性药物成分在不同的pH和温度条件下的溶解度（PPT）

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摘要

1.Motivation.2.Thermodynamics of pH-dependent solubility.3.SAFT-γ Mie theory.4.Case study: Ibuprofen.4.1 Solid-liquid equilibria.4.2 Phase diagram.4.3 pH-solubility profile at 25°C.4.4 Temperature effects on the pH-solubility profile.4.4.1 pH-solubility profile of ibuprofen at 37°C.5.Concluding remarks.

机译：1.方法。对37℃下布洛芬的pH-溶解度曲线的影响。4.4.1℃。

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《AIChE Annual Meeting》|2019年|1 CD-ROM|共27页
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Malak Wehbe; Claire Adjiman; George Jackson;
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中图分类化工过程（物理过程及物理化学过程）;
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专利

1. Studies on the interactions of some small biomolecules with antibacterial drug benzethonium chloride and its active pharmaceutical ingredient ionic liquid (API-IL) benzethonium L-proline at varying temperatures [J] . Yan Zhenning, Ma Limin, Shen Shuangxia, Journal of Molecular Liquids . 2018,第期

机译：几种小生物分子与抗菌药物氯化物的相互作用及其活性药物成分离子液（API-IL）苯并吡啶在不同温度下的研究
2. Micro-scale solubility assessments and prediction models for active pharmaceutical ingredients in polymeric matrices [J] . Bochmann Esther S., Neumann Dirk, Gryczke Andreas, European journal of pharmaceutics and biopharmaceutics: official journal of Arbeitsgemeinschaft fuer Pharmazeutische Verfahrenstechnik e.V . 2019,第期

机译：聚合物基质中活性药物成分的微级溶解度评估和预测模型
3. Model evaluation for the prediction of solubility of active pharmaceutical ingredients (APIs) to guide solid–liquid separator design [J] . Kuveneshan Moodley, Jürgen Rarey, Deresh Ramjugernath Asian Journal of Pharmaceutical Sciences . 2018,第3期

机译：预测活性药物成分（API）溶解度的模型评估，以指导固液分离器设计
4. Prediction of the solubility of active pharmaceutical ingredients under varying conditions of pH and temperature using the SAFT-y Mie equation of state(PPT) [C] . Malak Wehbe, Claire Adjiman, George Jackson AIChE Annual Meeting . 2019

机译：使用状态的Saft-Y Mie型（PPT）预测活性药物成分在不同的pH和温度条件下的溶解度（PPT）
5. Impact of polymers on the solution crystal growth rate of a poorly water-soluble active pharmaceutical ingredient. [D] . Schram, Caitlin J. 2015

机译：聚合物对水溶性差的活性药物成分的溶液晶体生长速率的影响。
6. Model evaluation for the prediction of solubility of active pharmaceutical ingredients (APIs) to guide solid–liquid separator design [O] . Kuveneshan Moodley, Jürgen Rarey, Deresh Ramjugernath 2018

机译：预测活性药物成分（API）溶解度的模型评估以指导固液分离器设计
7. Influence of pH, Temperature and Impurities on the Solubility of an Active Pharmaceutical Ingredient (API) [O] . Estime Nicolas, Autret Jean Marie, Teychené Sébastien, 2010

机译：pH，温度和杂质对活性药物成分（API）溶解度的影响

Prediction of the solubility of active pharmaceutical ingredients under varying conditions of pH and temperature using the SAFT-y Mie equation of state(PPT)

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