Studies on the interactions of some small biomolecules with antibacterial drug benzethonium chloride and its active pharmaceutical ingredient ionic liquid (API-IL) benzethonium L-proline at varying temperatures

摘要

From the conductivity, density and spectroscopy measurements, the interactions of benzethonium chloride ([BTC]) and its active pharmaceutical ingredient in ionic liquid format benzethonium L-proline ([BT][PRO]) with some amino acids and glycyl dipeptides have been examined. A number of useful parameters, such as standard partial molar volume (V-2,phi(o)), partial molar transfer volume (Delta V-t(o)), standard partial molar expansibility (E-phi(o)) of these small biomolecules, critical micelle concentration (cmc), aggregation number (N-agg), thermodynamic micellization parameters of [BTC]/[BT][PRO], as well as binding constant for small biomolecule-drug complex have been evaluated. Group contributions of charged end group (NH3+, COO-), CH2 and (CH2CONH) groups of amino acids/dipeptides to V-2,V-phi, values have also been perceived. These parameters are helpful to study the structure making capacity of small biomolecules, solvation behavior of [BTC]/[BT][PRO] and various interactions present in the studied ternary solution. The interaction difference of IBTC] and [BT][PRO] with small biomolecules was studied. (C) 2018 Elsevier B.V. All rights reserved.