ORAL PHARMACEUTICAL FORM BASED ON AT LEAST ONE ACTIVE INGREDIENT WHOSE SOLUBILITY VARIES IN ACCORDANCE WITH THE CONDITIONS OF GASTRIC PH

摘要

The field of the present invention is that of the oral pharmaceutical forms of at least one active ingredient PA whose solubility varies in function of the gastric pH, as well as the corresponding treatments and methods of administration.The invention relates to the use of in an oral pharmaceutical form comprising PA, a coating or a matrix including said AP and allowing the controlled release of said PA, to ensure that this form administered orally to a sample of subjects lead, whatever the fed or fasting subjects, decreased inter and / or intra-individual standard deviation of Cmax, thereby ensuring a lower variability of efficacy and therapeutic safety of the form compared to an immediate-release pharmaceutical form of PA administered to this same sample of subjects, at the same dose.