Improved Stability of Polymer-conjugated Lactate Dehydrogenase by Covalent Attachment of Poly(Ethylene Glycol)

摘要

Biohybrid materials, or materials utilizing biological materials in their rational design, are prime candidates to act as therapeutic carriers for detoxification processes. Liver disease is the 12th highest cause of death in the United States for 2009 and 2010. Liver toxicity is a primary contributor and promoter of liver disease. To this end, a biomimetic polymer enzyme system was produced and characterized to ascertain its ability for detoxification to aid in liver regeneration.