Mechanism of osteogenesis around polarized hydroxyapatite implant

摘要

Negatively charged surfaces of the electrically polarized hydroxyapatite ceramics enhanced the osteogenesis of canine bone marrow. The negatively charged hydroxyapatite surface conducted bone formation 1 week after implantation in the widely gapped environment. By 2 weeks, a ca. 0.2 mm gap was filled with maturing bone rigidly contacted with the hydroxyapatite surfaces. The electrostatic force was revealed to have effects both upon activation of the bone formation by myeloid cells and on construction on the c-face highly-orientated hydroxyapatite layer on the negatively charged surface.