Implementation of a pharmocokinetic approach to a baculovirus system for analytic solutions to virus and cell interactions

摘要

A quantitative investigation was undertaken to study the overall effects of the individual stages of the trafficking of a baculovirus system (AcMNPV) into the nucleus of a cell. The limiting rate constants, k{sub}r and k{sub}λ, showed thebehavior can dramatically change based upon these rate constants. This pharmocokinetic modeling was useful in predicting the overall virus concentrations in each stage of the virus and cell interactions. This model can be used further to predict othertypes of virus systems in order to increase the ability of predicting protein production in many processes including viral gene therapy.