It is well understood that immune tolerance plays an important role in chronic hepatitis B. Previous studies demonstrate that dendritic cells (DC) play key roles in the establishment of immune tolerance, such as clonal deletion or clonal anerge, expressing T-cell inhibiting factors, activating helper T cells selectively, and inducing regulatory T cells (Treg) , especially CD4 + CD25 + Treg. In addition, the primary target of CD4 + CD25 + Treg is DC. Thus, CD4 + CD25 + Treg could have various functions such as affecting maturation of DC mainly, restraining the antigen presentation of DC, inhibiting the activation of T cells in non-specific contacts, and inducing immune tolerance. Thus, DC and CD4 + CD25 + Treg interact as target by each other and work synergetically.%免疫耐受在乙型病毒性肝炎慢性化进程中发挥重要作用已经被多数学者所认可,研究表明,在免疫耐受过程中,树突状细胞(dendritic cells,DC)发挥克隆清除、克隆无能、表达T细胞抑制因子、选择性激活辅助T细胞和诱导调节性T细胞(regulatory T cells,Treg)尤其是CD4+CD25+Treg的产生等作用.而CD4+CD25+Treg主要以DC为作用靶点,影响其分化成熟,抑制DC向T细胞提呈抗原,并通过非特异性接触抑制T细胞活化,诱导免疫耐受.因此,DC和CD4+CD25+Treg在免疫耐受中相互作用、互为靶点,并发挥协同效应.
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