Evaluation of ROI methods for quantitative FDOPA PET images

摘要

Issues about the accuracy of ROI definition methods for FDOPA PET studies were investigated. An MRI-based ROI method and manually defined ROI method were compared using a computer simulated brain phantom and four real PET studies. The results indicate the error or discrepancy between MRI-based ROI and manually defined ROI is small ($LS $EQ 5%) at different head orientations and different noise levels. The VOI is not sensitive to the orientation, but the mid-plane ROI is also fairly reliable.