6 - L - fluorodopa labeled with 18 F, processes for their preparation lectrofila fluoridation in Solid Phase, a Radio Pharmaceutical Kit, a cartridge for radio Pharmaceutical Kit for the preparation of fdopa 18F, and a method to obtain a pet imaging diagnosis.

摘要

Refers to the process to obtain compounds of 6 - L, 18F fluorodopa formula (1) and Compound of formula (1).Also claimed is a process for the manufacture of a Tracer labeled with 18F formula (2) for use in PET; a Kit for radiopharmaceutical preparation fdopa 18F for Pet use; a cartridge for a Kit for radiopharmaceutical preparation for use in fdopa 18F - P Et; defined above and a method for obtaining an image of Pet diagnosis.Claim 1, a process for the production of 18F fluorodopa 6 - L - (18F fdopa) which involves Treatment of a precursor of fdopa attached to a Solid support of formula (1): wherein R1 and R2 are independently selected from alkyl - 6 C1, P1, P2, P3 and P4 are each one Independent Mind Shield with Hydrogen or a Group; a source of 18F, properly 18f2,18F ch3ccof or 18F labeled Tracer of2; to give the formula (2): where P1,P2, P3 and P4 are each independently Hydrogen or a protecting Group; optionally followed by: (i) removal of excess ions and fluorination Agent produced by the generation of 18F fluorination or agent in the reaction; and / or (ii) the Elimination of any Protective Group; and / or (I (ii) the Elimination of Organic Solvent; and / or (iv) formulation of a compound of formula (2) as a resultAn aqueous solution.