Ergodic Grey Relation between Plasma Renin Activity and Ambulatory Blood Pressure in Non-dipper Hypertensive Males: The project is supported by the National Natural Science Foundation of China (No.30271158)

摘要

Objective To investigate the relationship between circadian rhythm of plasma renin activity (PRA) and ambulatory blood pressure (ABP) in non-dipper essential hypertensive males by employing ergodic grey relational analysis (EGRA). Methods Twenty-nine non-dipper essential hypertensive males, aged 33-73 years (averaged at 52.35±9.84 years), were underwent 24-hour ambulatory blood pressure monitoring (ABPM). The systolic blood pressure (SBP) and diastolic blood pressure (DBP) were automatically measured at 1:00PM, 5:00PM, 9:00PM, 1:00AM, 5:00AM and 9:00AM. PRA was simultaneous examined by using radioimmunoassay (RIA). Results ① PRA curve appeared a double peaks respectively at 1:00PM and 9:00AM and two troughs separately at 9:00PM and 5:00AM in non-dipper essential hypertensive males. ② The strongest grey relation interval between PRA and SBP either DBP existed for 8 hours. Conclusion ① PRA was not the pacemaker of circadian rhythm of blood pressure. ② PRA plays a lingering rather than parallel effect on SBP and DBP. ③ EGRA is a wonderful method to analyze dynamic medical data.