原发性高血压患者血浆肾素活性水平与血压和尿钠的关系

摘要

Objective To study the relation of plasma renin activity level with blood pressure and natriuresis in essential hypertension patients. Methods Four hundred and seventy-nine essential hypertension patients were divided into low renin level group(rc = 93) ,medium rennin level group (n = 291),and high rennin level group(n = 95) according to their renin activity level. Relation of plasma rennin activity level with 24 h ambulatory blood pressure and natriuresis was analyzed in 3 groups. Results The age was slightly younger while the plasma renin activity level was significantly higher in medium and high renin level groups than in low renin level group(P<0. 05, P< 0. 01). The proportion of aged subjects, females, and non-dipper blood pressure was significantly higher in low renin level group than in high renin level group(P<0. 01). The 24 h plasma renin activity level was negatively related with the 24 h natriuresis and blood pressure(P<0. 05,P< 0. 01). Conclusion The plasma renin activity level is lower in aged subjects and females with essential hypertension. The change in circadian rhythm of blood pressure, especially non-dipper blood pressure,is more significant in patients with a low renin level.%目的 分析原发性高血压患者血浆肾素活性水平与血压、尿钠排泄的关系.方法 原发性高血压患者479例,根据血浆肾素活性水平的5分位排序,分为3组,低肾素组93例,中间肾素组291例,高肾素组95例.各组血浆肾素活性与24h动态血压及24 h尿钠排泄情况进行相关性分析.结果 与低肾素组比较,中间肾素组和高肾素组年龄明显偏低,血浆肾素活性明显增高,差异有统计学意义(P＜0.05,P＜0.01).低肾素组老年人、女性、非杓型血压比例明显高于高肾素组,差异有统计学意义(P＜0.01).血浆肾素活性水平与24 h尿钠排泄、24 h血压呈负相关(P＜0.05,P＜0.01).结论 老年和女性原发性高血压患者血浆肾素活性水平较低.低肾素患者血压昼夜节律改变更明显,以非杓型血压多见.