Optical Technology for Fibrotic Skin Changes Objectification in Experimental Systemic Scleroderma

摘要

Currently the examination of skin fibrosis is based on subjective non quantitative methods and requires invasive procedures. Optical techniques abled to evaluate different quantitative parameters of ordered tissues can be used to solve these problem. Measurements of endogenous fluorescence intensity, regional tissue oxyhemoglobin saturation, and blood filling volume allowed to define the high endogenous fluorescence intensity of porphyrin in skin fibrosis. Besides that, the decrease in oxygen intake parameters together with the fluorescence intensity increase of collagen was determined. Consequently the optical diagnostic techniques can become an effective method for skin fibrosis evaluation.