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Dosimetry of high intensity electron beams produced with dedicated accelerators in Intra-Operative Radiation Therapy (IORT)

机译:在术中,在术中放射治疗中的专用加速器生产的高强度电子束的剂量测定(IORT)

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The technique of High Dose Intra-Operative Radiation Therapy (HDR-IORT) consists in the delivery of irradiation immediately following the removal of a cancerous mass, where the same incision is used to direct the radiation to the tumour bed. Given its particular characteristics, IORT requires dose measurements that are different from those requested in external radiotherapy treatments. The main reason lies in the fact that in this case a single high dose must be delivered to a volume target whose extension and depths will be determined directly during the operation. Since the possibility of devising a treatment plan using a TPS (Treatment Planning System) is not available, it is necessary to know the physical and geometric characteristics of the beam. Defining the physical characteristics of the beam entails both measuring the delivered dose and defining (monitoring) procedures. In any case a much higher dose will be released than occurs with conventional external accelerators. The ionization chamber recommended by the standard protocols for radiotherapy cannot be used because of the ion recombination inside the gas. In this work we propose the use of a calorimetric phantom, the Dosiort, to measure the beam properties. We describe the main characteristics and some preliminary results of the Dosiort System, which is proposed within the framework of a research project of the INFN (Italian National Institute of Nuclear Physics). The set-up is a solid phantom of density approaching 1 g/cc with sensitive layers of scintillating fibres at fixed a position in a calorimetric configuration for the containment of electrons of energy 4−12 MeV. The prototype will be able to define the physical and geometrical characteristics of the electron beam (quality, isotropy, homogeneity, etc) and to measure the parameters needed to select the energy, the intensity and the Monitor Units (MU) for the exposition: Percentage Depth Dose; Beam profiles; Isodose curves; Values of dose f-or MU.
机译:高剂量术中术中放射治疗(HDR-IORT)的技术在除去癌肿块后立即递送辐射,其中使用相同的切口将辐射引导到肿瘤床。鉴于其特殊的特征,IORE需要与外部放射治疗治疗中所要求的剂量测量。主要原因在于,在这种情况下,必须将单个高剂量输送到其延伸和深度将在操作期间直接确定的体积目标。由于不可用DPS(处理计划系统)设计使用TPS(处理计划系统)的可能性,因此有必要了解光束的物理和几何特性。定义光束的物理特性需要测量输送剂量和定义(监测)程序。在任何情况下,将释放更高的剂量,而不是传统的外部促进剂。由于气体内部的离子重组,不能使用由标准方案用于放射疗法的电离室。在这项工作中,我们提出了使用量量幻像,定影剂来测量光束属性。我们描述了Dosiort系统的主要特点和一些初步结果,该系统在Infn研究项目(意大利国家核物理学研究所)的框架内提出。设定是密度的固体幻像接近1g / cc,其敏感层的闪烁纤维的敏感层固定在热量配置中的位置,用于容纳4-12mev的电子。原型将能够定义电子束(质量,各向同性,均匀性等)的物理和几何特征,并测量选择能量,强度和监视器单元(MU)所需的参数:百分比深度剂量;光束剖面;体状曲线;剂量F-或mm的值。

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