SYNTHESIS OF PYRAZOLIDIN-3-ONES WITH POTENTIAL ACTIVITY FOR THE TREATMENT OF BIPOLAR DISORDER

摘要

Bipolar disorder, also known as manic-depressive illness, is an incapacitating, chronic, and serious neuropsychiatric disease in which the patient has recurrent episodes of two opposing mood states, mania and depression. The available medical treatment for this disorder currently is not the most appropriate. The most used therapeutic approach is a mixture of antidepressants and antipsychotics, in which the first is used to treat depressive crisis and the second ones to treat manic episodes. Another worldwide drug used to control this disease is Lithium Carbonate which has serious side effects [1-4]. Because of the lack of efficacy of the treatments available and the various side effects, it is crucial to design new molecules with potential for the treatment of this illness [5-7].