ANTITUMOUR ACTIVITY OF BIS-ADDUCT OF 5-METHYLURACILE.

摘要

One of the perspective ways of the search of new antitumour medical drugs is the creation of new antimetabolites of pyrimidines or purines change which will influence on structure and functions of nucleonic acids. A new convenient method for the preparation with 18-crown-6-complex as catalyst of the original heterocyclic compound on the base of 5-methyluracile and fluoric containing Sinton -ftorotan was described. The method reported for the synthesis of bis-adduct of 5-methyluracile (compound 1) is based on the reaction which involve elimination of fluorine hydride, formation of the intermediate 1,1-difluoro-2-bromo-2-chloroethene which react with nucleophilic molecules.