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Recognition of Methylcytosine in Duplex DNA by Artificial Zinc Finger Peptide

机译：通过人工锌指肽识别双相DNA中的甲基胞嘧啶

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摘要

An artificial zinc finger peptide has been developed through rational design of the interaction with the methyl group of 5-methylcytosine in duplex DNA. The peptide containing a phosphotyrosine in the α-helix sequence-selectively bound to a methylated DNA.

机译：通过合理设计通过与双相DNA中的5-甲基胞嘧啶的甲基相互作用的合理设计而开发了人工锌指肽。含有在α-螺旋中的磷酸酪氨酸的肽 - 选择性地结合甲基化DNA。

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《Japanese peptide symposium》|2011年||共1页
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作者
Akiko Nomura; Akimitsu Okamoto;
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原文格式 PDF
正文语种
中图分类肽类;
关键词
zinc finger; 5-methylcytosine; duplex DNA; phosphotyrosine;

机译：锌手指;5-甲基胞嘧啶;DOPLEX DNA;磷酸酪氨酸;
入库时间 2022-08-20 19:55:18

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专利

1. alpha-Helical Linker of an Artificial 6-Zinc Finger Peptide Contributes to Selective DNA Binding to a Discontinuous Recognition Sequence [J] . Wei Yan, Miki Imanishi, Shiroh Futaki Biochemistry . 2007,第29期

机译：人造6-锌指肽的α-螺旋连接物有助于选择性DNA与不连续识别序列的结合
2. Artificial zinc finger peptides: creation, DNA recognition, and gene regulation [Review] [J] . Nagaoka M., Sugiura Y. Journal of Inorganic Biochemistry: An Interdisciplinary Journal . 2000,第1a4期

机译：人工锌指肽：创造，DNA识别和基因调控[综述]
3. DNA-bending finger: artificial design of 6-zinc finger peptides with polyglycine linker and induction of DNA bending. [J] . Imanishi M, Hori Y, Nagaoka M, Biochemistry . 2000,第15期

机译：DNA弯曲的手指：6-锌指肽的人工设计，具有聚葡萄糖接头和DNA弯曲的诱导。
4. Recognition of Methylcytosine in Duplex DNA by Artificial Zinc Finger Peptide [C] . Akiko Nomura, Akimitsu Okamoto Japanese peptide symposium . 2011

机译：通过人工锌指肽识别双相DNA中的甲基胞嘧啶
5. New Vistas in Zinc Finger Biochemistry: Examining the Metal-Mediated DNA Recognition of the Neural Zinc Finger Factor/Myelin Transcription Factor Family of Non-Classical Zinc Finger Proteins and Creating Catalytic Moieties from Zinc Finger Scaffolds [D] . Besold, Angelique N. 2014

机译：锌指生物化学的新视野：检查非经典锌指蛋白的神经锌指因子/髓鞘转录因子家族的金属介导的DNA识别，并从锌指支架中产生催化部分
6. Sequence-specific recognition of DNA by zinc-finger peptides derived from the transcription factor Sp1. [O] . R W Kriwacki, S C Schultz, T A Steitz, 1992

机译：衍生自转录因子Sp1的锌指肽对DNA的序列特异性识别。
7. Sequence-specific recognition of DNA by zinc-finger peptides derived from the transcription factor Sp1. [O] . Kriwacki, R W, Schultz, S C, Steitz, T A, 1992

机译：衍生自转录因子Sp1的锌指肽对DNA的序列特异性识别。

Recognition of Methylcytosine in Duplex DNA by Artificial Zinc Finger Peptide

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