Studies on the Effect of Pathogenic Mutations in the Transmembrane Region Structure of FGFR3

摘要

We are currently working on the structural analysis of the transmembrane, region of fibroblast growth factor receptor 3 (FGFR3). Solid state NMR experiments were carried out to establish the dimer interface of transmembrane region with sequences of the wild type, the G380R mutant which is a partially preactivated mutant and the A391E mutant which is related to bladder cancer. The findings indicate that the dimer interface in the transmembrane region is distinct for each sequence.