LC/MS/MS Method for Quantitative Determination of Ultralow Levels of Azelastine and its Metabolite, Desmethylazelastine in Human Plasma

机译：LC / MS / MS / MS方法用于定量测定偶氮气体的超级水平及其代谢物，人血浆中的去甲基嗪吡啶

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The method shows good linearity for AZ and DAZ with 1000-fold wide calibration range. The method is highly sensitive for the metabolite of DAZ with LLOQ of 0.1 pg/mL, and for AZ with LLOQ of 1.0 pg/mL. The method was validated and achieved the sensitivity and reproducibility needed for pharmacokinetic studies in human plasma.

机译：该方法显示AZ和DAZ的良好线性，校准范围1000倍。该方法对DAZ的代谢物高度敏感，LLOQ为0.1pg / ml，对于LLOQ为1.0 pg / ml的AZ。验证了该方法，实现了人血浆药代动力学研究所需的敏感性和再现性。

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《American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics》|2013年||共1页
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Jingduan Chi; Zong-Ping Zhang;
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中图分类 TB994.5-53;
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4. LC/MS/MS Method for Quantitative Determination of Ultralow Levels of Azelastine and its Metabolite, Desmethylazelastine in Human Plasma [C] . Jingduan Chi, Zong-Ping Zhang American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2013

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LC/MS/MS Method for Quantitative Determination of Ultralow Levels of Azelastine and its Metabolite, Desmethylazelastine in Human Plasma

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