Diastereomeric Separation of Chiral Metabolites Utilizing SFC-MS/MS; A Powerful Tool to Investigate Stereoselective Metabolism?

机译：使用SFC-MS / MS的手性代谢物的非对映异构分离;调查立体选择性新陈代谢的强大工具？

获取原文

页面导航

摘要
著录项
相似文献
相关主题

摘要

SFC-MS/MS has successfully been applied to investigate stereoselective metabolism in a DMPK environment: (1) A validated assay for a parent compound and 3 diastereomeric metabolites was developed. (2)In this instance, in vivo chiral inversion was investigated in pooled clinical and preclinical samples (dog). (3)Use of SFC has moved from sample preparation and purification to bioanalytical assay and metabolite identification.

机译：已经成功地应用了SFC-MS / MS以研究DMPK环境中的立体选择性代谢：（1）开发了母体化合物和3个非对映异构代谢物的验证的测定。（2）在这种情况下，在合并的临床和临床前样品（狗）中研究了体内手性反演。（3）SFC的使用从样品制备和纯化转移到生物分析测定和代谢物鉴定。

著录项

来源
《American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics》|2013年||共1页
会议地点
作者
Chester L Bowen; Hermes Licea-Perez; Tom DiPhillipo; Denise Heyburn; Paul Rainville; Christopher Evans; Robert Plumb;
展开▼
作者单位

展开▼
会议组织
原文格式 PDF
正文语种
中图分类 TB994.5-53;
关键词

相似文献

外文文献
中文文献
专利

1. Development and validation of an enantioselective SFC-MS/MS method for simultaneous separation and quantification of oxcarbazepine and its chiral metabolites in beagle dog plasma [J] . Yang Zhichao, Xu Xueyu, Sun Lingxia, Journal of chromatography, B. Analytical technologies in the biomedical and life sciences . 2016,第Null期

机译：对映选择性SFC-MS / MS方法的开发和验证，用于同时分离和定量比格犬血浆中的奥卡西平及其手性代谢物
2. Stereoselective supercritical fluidic chromatography -mass spectrometry (SFC-MS) as a fast bioanalytical tool to assess chiral inversion in vivo and in vitro [J] . Chen Liuxi, Dean Brian, La Hank, International journal of mass spectrometry . 2019,第期

机译：立体选择性超临界流体色谱 - 散谱仪（SFC-MS）作为一种快速生物分析工具，以评估体内和体外的手性反演
3. Investigation of Isoprostanes as Potential Biomarkers for Alzheimer's Disease Using Chiral LC-MS/MS and SFC-MS/MS [J] . Victoria Goss, Amaury Cazenave-Gassiot, Ashley Pringle, Current Analytical Chemistry . 2014,第1期

机译：使用手性LC-MS / MS和SFC-MS / MS研究异前列腺素作为阿尔茨海默氏病的潜在生物标记物
4. Diastereomeric Separation of Chiral Metabolites Utilizing SFC-MS/MS; A Powerful Tool to Investigate Stereoselective Metabolism? [C] . Chester L Bowen, Hermes Licea-Perez, Tom DiPhillipo, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2013

机译：使用SFC-MS / MS的手性代谢物的非对映异构分离;调查立体选择性新陈代谢的强大工具？
5. High performance liquid chromatography diastereomeric separation for chiral analysis and kinetic analysis. [D] . Li, Li. 2005

机译：高效液相色谱非对映异构体分离，用于手性分析和动力学分析。
6. Enantioseparation and Determination of Penconazole in Rat Plasma by Chiral LC-MS/MS: Application to a Stereoselective Toxicokinetic Study [O] . Siman Ma, Jia Lun, Yanru Liu, 2020

机译：手性LC-MS / MS对大鼠血浆中潘康唑的鉴定和测定方法：应用于立体选择性毒性研究
7. A novel, fast and sensitive supercritical fluid chromatography-tandem mass spectrometry (SFC-MS/MS) method for analysis of arachidonic acid metabolites [O] . S. J. Kumari A. Ubhayasekera, Santosh R. Acharya, Jonas Bergquist 2018

机译：一种新型，快速敏感的超临界流体色谱 - 串联质谱（SFC-MS / MS）方法，用于分析花生酸代谢物

Diastereomeric Separation of Chiral Metabolites Utilizing SFC-MS/MS; A Powerful Tool to Investigate Stereoselective Metabolism?

摘要

著录项

相似文献

相关主题

期刊订阅