A Highly Sensitive Method for the Quantita tion of Buprenorphine, Norbuprenorphine and Naloxone in Human Plasma by High-pH LC-MS/MS

摘要

1. The method was validated and achieved the sensitivity and reproducibility needed for pharmacokinetic studies of the compounds in human plasma. 2. Concomitant medication interference check including OTC drugs and naltrexone has shown no impact to the quantitation method.