Detection of the Kappa Opioid Receptor (KOR) Antagonists in Mouse Brain Using LC-MS/MS Weeks After Administration.

摘要

To the best of our knowledge, this is the first direct physical proof of the prolonged retention of long acting KOR antagonist nor-BNI in mouse brain. Presence of nor-BNI in the brain tissue and its concomitant absence in the blood from the same mouse after i.c.v. injection indicates the amount detected in the brain is due to the accumulation of nor-BNI in the brain tissue and not from the traces of blood in the isolated brain.